Study Perks & S.P.E.C.I.A.L System
If you've played Fallout 4 before, you're probably familiar with the Perks system and the S.P.E.C.I.A.L. system. If you're not, here's a basic explanation.
As you level up your character, you'll be able to allot points into Strength, Perception, Endurance, Charisma, Intelligence, Agility, and Luck. Bethesda's teased all of these with a series of videos that you can watch right here.
We still don't know how all of these work exactly but what we do is that all of these will have a profound impact on your character and his/her abilities.
You'll also be able to choose from a long list of Perks. You'll want to choose these carefully, thinking about how you play the game. You can get a feel for these perks by viewing this list right here.
If you educate yourself a little bit before you play, you're going to build a character that suits your play style. Some of you might like to make mistakes but if you're not the type of person that replays games, you'll want to look into these this very moment.